Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome.

@article{Bertozzi1990DepressedBU,
  title={Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome.},
  author={P Bertozzi and Birger {\AA}stedt and L Zenzius and Kevin Lynch and François Lemaire and Warren M. Zapol and Harold A Chapman},
  journal={The New England journal of medicine},
  year={1990},
  volume={322 13},
  pages={890-7}
}
Abundant deposition of bronchoalveolar fibrin and fibronectin occurs during the exudative phase of the adult respiratory distress syndrome (ARDS), promoting hyaline-membrane formation and subsequent alveolar fibrosis. To explore the mechanisms that account for the persistence of bronchoalveolar fibrin and fibronectin, we compared the activity of urokinase, which is necessary for plasminogen activation and fibrin degradation, in cell-free bronchoalveolar-lavage fluid from 8 patients with ARDS, 9… CONTINUE READING