Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy.

@article{Dutta2002DepressedPA,
  title={Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy.},
  author={Kaushik Dutta and Marybeth W. Carmody and Steven E. Cala and Amy J Davidoff},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 8},
  pages={985-96}
}
We have previously described a cardiomyopathy induced by culturing ventricular myocytes from normal adult rats in a medium containing high concentrations of glucose, which recapitulates cellular changes associated with early onset diabetic cardiomyopathy. This investigation was designed to evaluate cellular mechanisms that could contribute to slowed cytosolic Ca(2+) removal and myocyte relaxation in glucose-induced cardiomyopathy. Isolated ventricular myocytes were cultured overnight in medium… CONTINUE READING

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