Deprenyl and pergolide rescue spinal motor neurons from axotomy-induced neuronal death in the neonatal rat.

@article{Iwasaki1996DeprenylAP,
  title={Deprenyl and pergolide rescue spinal motor neurons from axotomy-induced neuronal death in the neonatal rat.},
  author={Yasuo Iwasaki and Ken Ikeda and Toshiya Shiojima and Tohru Kobayashi and Nobumi Tagaya and Masao Kinoshita},
  journal={Neurological research},
  year={1996},
  volume={18 2},
  pages={168-70}
}
It has been reported that both the monoamine oxidase inhibitor, deprenyl and the dopamine receptor agonist, pergolide have neuroprotective actions. To investigate the effect of deprenyl and pergolide on axotomized motor neuron death, we examined the survival of spinal motor neurons after sciatic nerve transection in the neonatal rats. Newborn rats were anesthetized with hypothermia. Sciatic nerve was cut near the obturator tendon in the left thigh. Animals were then treated daily with deprenyl… CONTINUE READING