Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes.

@article{Frhbeck2002DepotspecificDI,
  title={Depot-specific differences in the lipolytic effect of leptin on isolated white adipocytes.},
  author={Gema Fr{\"u}hbeck and Javier G{\'o}mez-Ambrosi},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2002},
  volume={8 2},
  pages={BR47-55}
}
BACKGROUND In the present study we hypothesized that leptin-induced lipolytic effects show depot-specific differences. MATERIAL/METHODS Three-month-old male lean (+/+) and obese fa/fa rats were used. Lipolysis was determined in the absence or presence of leptin (0.63, 6.25 and 62.5 nM) together with agents acting at the A1 adenosine receptor of fat cells isolated from both subcutaneous and omental depots. The glycerol released into the incubation medium was taken as the lipolytic rate index… CONTINUE READING