Depot naltrexone: antagonism of the reinforcing, subjective, and physiological effects of heroin

@article{Sullivan2006DepotNA,
  title={Depot naltrexone: antagonism of the reinforcing, subjective, and physiological effects of heroin},
  author={Maria A. Sullivan and Suzanne K Vosburg and Sandra Dean Comer},
  journal={Psychopharmacology},
  year={2006},
  volume={189},
  pages={37-46}
}
RationaleNaltrexone is an opioid antagonist that is currently approved as a treatment for opioid and alcohol dependence. Although it is highly effective in completely antagonizing the effects of opioids, medication noncompliance is a difficult obstacle to treatment. Therefore, a sustained-release form of naltrexone may improve treatment outcome.ObjectiveThe present study was designed to evaluate the time course, safety, and effectiveness of a depot formulation of naltrexone (Depotrex… CONTINUE READING
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