Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema: proof of concept for a novel diagnostic technique.

@article{Aaltonen2018DepositionOI,
  title={Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema: proof of concept for a novel diagnostic technique.},
  author={H L Aaltonen and Jonas K. F. Jakobsson and Sandra Diaz and Sophia Zackrisson and Eeva Piitulainen and Jakob L{\"o}ndahl and Per Wollmer},
  journal={Clinical physiology and functional imaging},
  year={2018}
}
BACKGROUND The diagnosis of chronic obstructive pulmonary disease (COPD) is often based on spirometry, which is not sensitive to early emphysema. We have recently described a method for assessing distal airspace dimensions by measuring recovery of nanoparticles in exhaled air after a single-breath inhalation followed by breath-hold. Recovery refers to the non-deposited particle fraction. The aim of this study was to explore differences in the recovery of exhaled nanoparticles in subjects with… CONTINUE READING