Deposition of elafin in the involved vascular wall of neutrophil-mediated cutaneous vasculitis.


BACKGROUND Neutrophil elastase plays an important role in skin inflammation induced by neutrophil infiltration. Elafin is an inducible elastase inhibitor expressed by keratinocytes, and is known to be involved in pathogenesis of neutrophilic skin disorders such as psoriasis. METHODS Immunohistochemical studies of elafin expression in the cases of… (More)
DOI: 10.1111/jdv.13650