Deposition of C4d and C3d in cardiac transplants: a factor in the development of coronary artery vasculopathy.

@article{Moseley2010DepositionOC,
  title={Deposition of C4d and C3d in cardiac transplants: a factor in the development of coronary artery vasculopathy.},
  author={Ellen L Moseley and C Scott Atkinson and Linda D. Sharples and John Wallwork and Martin J Goddard},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2010},
  volume={29 4},
  pages={417-23}
}
BACKGROUND Coronary artery vasculopathy (CAV) is the major life-limiting factor in cardiac transplantation, after 1 year. Antibody-mediated rejection (AMR) has been associated with development of both acute and chronic rejection. We analyzed endomyocardial biopsies for pathologic markers of AMR (C4d and C3d), from the first 2 years post-transplantation, to determine complement deposition in relation to the development of CAV. METHODS A retrospective, matched-pair study was used. Group 1… CONTINUE READING
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