Deposition and translocation of inhaled silica in rats. Quantification of particle distribution, macrophage participation, and function.

@article{Brody1982DepositionAT,
  title={Deposition and translocation of inhaled silica in rats. Quantification of particle distribution, macrophage participation, and function.},
  author={Arnold R. Brody and Michael W. Roe and John Gerald Evans and Gerald S. Davis},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1982},
  volume={47 6},
  pages={
          533-42
        }
}
Chronic exposure to silica dust causes fibrotic lung disease. Using brief exposures, we have attempted to define the initial patterns of dust deposition, anatomical compartments through which silica is translocated, and the participation of pulmonary macrophages in clearing the inhaled dust. To accomplish this, particle distribution and translocation at the alveolar level were studied in rats exposed to aerosolized alpha-quartz. Animals were exposed to 109 mg. per cu. m. of crystalline silica… CONTINUE READING

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