Depolymerizing Kinesins Kip3 and MCAK Shape Cellular Microtubule Architecture by Differential Control of Catastrophe

@article{Gardner2011DepolymerizingKK,
  title={Depolymerizing Kinesins Kip3 and MCAK Shape Cellular Microtubule Architecture by Differential Control of Catastrophe},
  author={Melissa K Gardner and Marija Zanic and Christopher Gell and Volker Bormuth and Jonathon Howard},
  journal={Cell},
  year={2011},
  volume={147},
  pages={1092-1103}
}
Microtubules are dynamic filaments whose ends alternate between periods of slow growth and rapid shortening as they explore intracellular space and move organelles. A key question is how regulatory proteins modulate catastrophe, the conversion from growth to shortening. To study this process, we reconstituted microtubule dynamics in the absence and presence of the kinesin-8 Kip3 and the kinesin-13 MCAK. Surprisingly, we found that, even in the absence of the kinesins, the microtubule… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Plus endspecific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle

  • M. L. Gupta, Jr., P. Carvalho, D. M. Roof, D. Pellman
  • Nat. Cell Biol. 8, 913–923.
  • 2006
Highly Influential
10 Excerpts

Similar Papers

Loading similar papers…