Depolymerization of F-actin by deoxyribonuclease I.

@article{Hitchcock1976DepolymerizationOF,
  title={Depolymerization of F-actin by deoxyribonuclease I.},
  author={Susan Hitchcock and L Carisson and Uno Lindberg},
  journal={Cell},
  year={1976},
  volume={7 4},
  pages={531-42}
}
Deoxyribonuclease I causes depolymerization of filamentous muscle actin to form a stable complex of 1 mole DNAase I:1 mole actin. The regulatory proteins tropomyosin and troponin bind to filamentous actin and slow down but do not prevent the depolymerization. In the absense of ATP, heavy meromyosin binds tightly to actin filaments and blocks completely the DNAase I: actin filament interaction. Addition of ATP releases heavy meromyosin; DNAase I is then rapidly inhibited and the actin filaments… CONTINUE READING

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