Depolarizing response of rat parathyroid cells to divalent cations

  title={Depolarizing response of rat parathyroid cells to divalent cations},
  author={Jos{\'e} L{\'o}pez-Barneo and Clay Armstrong},
  journal={The Journal of General Physiology},
  pages={269 - 294}
Membrane potentials were recorded from rat parathyroid glands continuously perfused in vitro. At 1.5 mM external Ca++, the resting potential averages -73 +/- 5 mV (mean +/- SD, n = 66). On exposure to 2.5 mM Ca++, the cells depolarize reversibly to a potential of -34 +/- 8 mV (mean +/- SD). Depolarization to this value is complete in approximately 2-4 min, and repolarization on return to 1.5 mM Ca++ takes about the same time. The depolarizing action of high Ca++ is mimicked by all divalent… CONTINUE READING