Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.

@article{Peachey2012DepolarizingBC,
  title={Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.},
  author={Neal S Peachey and Jillian N Pearring and Pasano Pasano Bojang and Matthew E. Hirschtritt and Gwen Sturgill-Short and Thomas A. Ray and Takahisa Furukawa and Chieko Koike and Andrew F X Goldberg and Yin Shen and Maureen A. McCall and Scott Nawy and Patsy M. Nishina and Ronald G Gregg},
  journal={Journal of neurophysiology},
  year={2012},
  volume={108 9},
  pages={
          2442-51
        }
}
Mutations in TRPM1 are found in humans with an autosomal recessive form of complete congenital stationary night blindness (cCSNB). The Trpm1(-/-) mouse has been an important animal model for this condition. Here we report a new mouse mutant, tvrm27, identified in a chemical mutagenesis screen. Genetic mapping of the no b-wave electroretinogram (ERG) phenotype of tvrm27 localized the mutation to a chromosomal region that included Trpm1. Complementation testing with Trpm1(-/-) mice confirmed a… CONTINUE READING

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