Depolarizing action of secretory granule protein 7B2 on rat supraoptic neurosecretory neurons.

@article{Senatorov1993DepolarizingAO,
  title={Depolarizing action of secretory granule protein 7B2 on rat supraoptic neurosecretory neurons.},
  author={Vladimir V. Senatorov and Chia Ru Yang and Mieczyslaw Marcinkiewicz and Michel Chr{\'e}tien and Leo P. Renaud},
  journal={Journal of neuroendocrinology},
  year={1993},
  volume={5 5},
  pages={533-6}
}
A novel precursor neuropeptide termed 7B2 is present within specific brain areas, including the hypothalamic magnocellular neurosecretory neurons, and appears to be processed to smaller fragments. In order to determine whether specific C-terminal fragments of 7B2 might exert local effects on neurosecretory cells, we used intracellular current-clamp recordings in supraoptic neurons maintained in superfused hypothalamic explants to evaluate membrane potential and resistance changes in 25… CONTINUE READING