Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.

  title={Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.},
  author={Kyoichi Kaira and Kazuo Nakagawa and Yasuhisa Ohde and Takehiro Okumura and Toshiaki Takahashi and Haruyasu Murakami and Masahiro Endo and Haruhiko Kondo and Takashi Nakajima and Nobuyuki Yamamoto},
  journal={International journal of surgical pathology},
  volume={20 3},
MUC1 is transmembrane mucin aberrantly overexpressed in various cancers. However, little is known about how MUC1 expression is associated with hypoxia, glucose metabolism, and epidermal growth factor receptor (EGFR) pathway, which are related to cancer progression. The aim of this study is to evaluate the relationship between MUC1 expression and these molecular markers in lung cancer. Of all 126 patients, high-grade polarized expression (HP), low-grade polarized expression (LP), and depolarized… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS


Publications citing this paper.
Showing 1-9 of 9 extracted citations

ATRA and Genistein synergistically inhibit the metastatic potential of human lung adenocarcinoma cells.

International journal of clinical and experimental medicine • 2015
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 30 references

A novel classification of MUC1 expression is correlated with tumor differentiation and postoperative prognosis in non-small cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2006
View 11 Excerpts
Highly Influenced

The international system for staging lung cancer.

Seminars in surgical oncology • 2000
View 5 Excerpts
Highly Influenced

Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer

M Woenckhaus, J Merk, R Stoehr
Hum Pathol • 2008
View 8 Excerpts
Highly Influenced

Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells.

Biochemical and biophysical research communications • 2011

Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2010
View 2 Excerpts

Functional targeting of the MUC1 oncogene in human cancers.

Cancer biology & therapy • 2009
View 2 Excerpts

Similar Papers

Loading similar papers…