Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.

@article{Kaira2012DepolarizedME,
  title={Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer.},
  author={Kyoichi Kaira and Kazuo Nakagawa and Yasuhisa Ohde and Takehiro Okumura and Toshiaki Takahashi and Haruyasu Murakami and Masahiro Endo and Haruhiko Kondo and Takashi Nakajima and Nobuyuki Yamamoto},
  journal={International journal of surgical pathology},
  year={2012},
  volume={20 3},
  pages={223-32}
}
MUC1 is transmembrane mucin aberrantly overexpressed in various cancers. However, little is known about how MUC1 expression is associated with hypoxia, glucose metabolism, and epidermal growth factor receptor (EGFR) pathway, which are related to cancer progression. The aim of this study is to evaluate the relationship between MUC1 expression and these molecular markers in lung cancer. Of all 126 patients, high-grade polarized expression (HP), low-grade polarized expression (LP), and depolarized… CONTINUE READING
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