Depolarization with high-K+ causes Ca(2+)-independent but partially Cl(-)-dependent glutamate release in rat hippocampal slice cultures.

@article{Takahashi1996DepolarizationWH,
  title={Depolarization with high-K+ causes Ca(2+)-independent but partially Cl(-)-dependent glutamate release in rat hippocampal slice cultures.},
  author={Masayasu Takahashi and Mizuki Hashimoto},
  journal={Neuroscience research},
  year={1996},
  volume={25 4},
  pages={399-402}
}
We studied the neurotoxic glutamate release induced by high-K+ depolarization in rat hippocampal slice cultures. Depolarization with 90 mM K+ for 30 min caused a significant, three-fold increase in glutamate release. This release was not inhibited by removing extracellular Ca2+, but was significantly inhibited by replacement of extracellular Cl- with SO4(2… CONTINUE READING