Depolarization of the liver cell membrane by metformin.

  title={Depolarization of the liver cell membrane by metformin.},
  author={Thomas A Lutz and A Estermann and Susanne Haag and Erwin Scharrer},
  journal={Biochimica et biophysica acta},
  volume={1513 2},
Metformin (1,1-dimethylbiguanide; MET) is used in the treatment of type 2 diabetes mellitus. MET's antihyperglycemic action depends at least in part on its inhibitory effect on hepatic gluconeogenesis. As to gluconeogenesis from amino acids (e.g. L-alanine), this is associated with an inhibition of L-alanine uptake into hepatocytes. Since this uptake is mediated by an electrogenic transport mechanism, the aim of the present study was to investigate whether MET has an influence on the liver cell… CONTINUE READING
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