Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase.

@article{Kroetz2002DepolarizationOE,
  title={Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase.},
  author={Florian Kroetz and Hae Young Sohn and Matthias Keller and Torsten Gloe and Steffen Sebastian Bolz and Bernhard Friedrich Becker and Ulrich Pohl},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 12},
  pages={2003-9}
}
OBJECTIVE The objective of this study was to investigate whether depolarization of cultured endothelial cells (human umbilical vein endothelial cells, HUVECs) affects their ectonucleotidase activity through superoxide (O2-) production. METHODS AND RESULTS Depolarization by the cation channel gramicidin (100 nmol/L) or tetrabutylammonium chloride (1 mmol/L) induced O2- release from HUVECs (n=4), which was decreased by superoxide dismutase (SOD, 500 U/mL). The activity of endothelial… CONTINUE READING
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