Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase.


OBJECTIVE The objective of this study was to investigate whether depolarization of cultured endothelial cells (human umbilical vein endothelial cells, HUVECs) affects their ectonucleotidase activity through superoxide (O2-) production. METHODS AND RESULTS Depolarization by the cation channel gramicidin (100 nmol/L) or tetrabutylammonium chloride (1 mmol/L… (More)


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