Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide.

@article{Kawatani1985DepolarizationAM,
  title={Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide.},
  author={Masahito Kawatani and M J Rutigliano and William Chet de Groat},
  journal={Science},
  year={1985},
  volume={229 4716},
  pages={879-81}
}
The effects of vasoactive intestinal polypeptide (VIP) in the superior cervical ganglion of the cat were studied in vitro and in vivo with sucrose gap and multiunit recording, respectively. At a dose of 0.03 to 0.12 nanomole, VIP produced a dose-dependent, prolonged (3 to 15 minutes) depolarization of the ganglion and enhanced the ganglionic depolarization elicited by the muscarinic agonist acetyl-beta-methylcholine. At a dose of 1.8 to 10 nanomoles, the peptide enhanced and prolonged the… CONTINUE READING

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