Depolarization-Induced Ca2+ Release in Ischemic Spinal Cord White Matter Involves L-type Ca2+ Channel Activation of Ryanodine Receptors

@article{Ouardouz2003DepolarizationInducedCR,
  title={Depolarization-Induced Ca2+ Release in Ischemic Spinal Cord White Matter Involves L-type Ca2+ Channel Activation of Ryanodine Receptors},
  author={Mohamed Ouardouz and Maria A. Nikolaeva and Elaine Coderre and Gerald W. Zamponi and John E. McRory and Bruce D Trapp and Xinghua Yin and Weili Wang and John Woulfe and Peter K. Stys},
  journal={Neuron},
  year={2003},
  volume={40},
  pages={53-63}
}
The mechanisms of Ca(2+) release from intracellular stores in CNS white matter remain undefined. In rat dorsal columns, electrophysiological recordings showed that in vitro ischemia caused severe injury, which persisted after removal of extracellular Ca(2+); Ca(2+) imaging confirmed that an axoplasmic Ca(2+) rise persisted in Ca(2+)-free perfusate. However, depletion of Ca(2+) stores or reduction of ischemic depolarization (low Na(+), TTX) were protective, but only in Ca(2+)-free bath… CONTINUE READING

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