Depolarization, exocytosis and amino acid release evoked by hyposmolarity from cortical synaptosomes.

@article{Tuz2004DepolarizationEA,
  title={Depolarization, exocytosis and amino acid release evoked by hyposmolarity from cortical synaptosomes.},
  author={Karina L. Tuz and Claudia Pe{\~n}a-Segura and Rodrigo Coelho Franco and Herminia Pasantes-Morales},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 4},
  pages={916-24}
}
External osmolarity reduction (20%) led to labelled glutamate, GABA and taurine release from rat brain cortical synaptosomes. A Cl--independent, Na+-dependent, La3+-sensitive and tetrodotoxin (TTX) reduced depolarization of synaptosomes occurred upon hyposmolarity, suggestive of Na+ entry through nonselective cation channels. This depolarization, together with cytosolic Ca2+ ([Ca2+]I) increase, resulted in exocytosis, monitored by FM1-43. The release fraction resulting from these phenomena was… CONTINUE READING
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…