Depolarisation of guinea-pig visceral smooth muscle causes hydrolysis of inositol phospholipids

@article{Best1986DepolarisationOG,
  title={Depolarisation of guinea-pig visceral smooth muscle causes hydrolysis of inositol phospholipids},
  author={Leonard Best and Thomas B. Bolton},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1986},
  volume={333},
  pages={78-82}
}
SummaryIncreasing concentrations of KCl caused a progressive stimulation of contractile activity in guinea-pig jejunal longitudinal smooth muscle strips, accompanied by increased production of [3H]inositol phosphates in smooth muscle fragments pre-labelled with myo-[3H]inositol. The concentration-response curve for contractility lay to the left of that for [3H]inositol phosphate production. Both responses showed a dependency on the presence of Ca2+ in the incubation medium. K+-induced… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

Changes in levels ofinositol phosphates after agonist - dependent hydrolysis of membrane phosphoinositides

M Berridge, Dawson RMC, CP Downes, JP Heslop, RF Irvine
  • Biochem J
  • 1983