Depo-provera treatment for sex-offending behavior: An evaluation of outcome Walter J. Meyer, III, Collier Cole, Evangeline Emory University of Texas Medical Branch, Galveston, TX 77555-0429

  title={Depo-provera treatment for sex-offending behavior: An evaluation of outcome Walter J. Meyer, III, Collier Cole, Evangeline Emory University of Texas Medical Branch, Galveston, TX 77555-0429
  author={Walter J. Meyer and C. Maureen Cole and Eugene K. Emory},
  journal={Biological Psychiatry},
Key MethodForty men, ages 16 to 78 years, with sex-offending behavior, were treated with combined medroxyprogesterone acetate (MPA), group therapy, and individual psychotherapy. Twenty-three are pedophiles; seven, rapists; and 10, exhibitionists. Five had sex-offending behavior that began after head trauma. The duration of MPA therapy, usual intramuscular dose 400 mg/wk, ranged from six months to 12 years, usually more than two years.Expand
Treatment of men with paraphilia with a long-acting analogue of gonadotropin-releasing hormone.
Continuous administration of triptorelin, a long-acting agonist analogue of gonadotropin-releasing hormone, together with supportive psychotherapy, may be an effective treatment for men with severe paraphilia. Expand
The Use of Leuprolide Acetate in the Management of High-Risk Sex Offenders
Results indicated that subjects receiving Lupron were at significantly higher risk of recidivism and significantly more likely to be diagnosed with a paraphilia than subjects receiving only CBT, a priori. Expand
The use of depo-provera in the treatment of child molesters and sexually compulsive males
Abstract Depo-Provera is an anti-androgen medication that has been approved by the FDA for use as an injectable contraceptive for women. It has also been used in the treatment of sex offenders.Expand
The biological treatment of dangerous sexual offenders: A review and preliminary report of the Oregon pilot depo-Provera program
Despite advances in the cognitive and behavioral treatment of sexual offenders made over the past 10 years, a number of such individuals released from custody and on parole in their communitiesExpand
An Ethical Analysis of the Use of Medroyprogesterone Acetate and Cyproterone Acetate to Treat Repeat Sex Offenders
Among the most heinous, and unfortunately common, crimes known to human society are rape and child molestation. Recidivism rates for offenders of these crimes are extremely high. Treatment ofExpand
Medroxyprogesterone treatment for paraphiliacs.
MPA safely and effectively reduced sex drive, controlled deviant sexual impulses and behavior, and lowered the testosterone levels of these paraphilic men during the first six months of treatment. Expand
Pharmacotherapy for Sexual Offenders
The last two decades have brought intense focus on identifying, containing, and managing the burgeoning number of individuals who sexually offend. Similar to other emotional and behavioral problems,Expand
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An in-depth review of the clinical pharmacology of the main antiandrogens used in the treatment of the paraphilias is provided, as well as a discussion of the relevant clinical case reports, case series, and controlled trials. Expand
Sex Offending and Sexual Appetite: The Clinical and Theoretical Relevance of Hypersexual Desire
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Data are presented suggesting that clinical samples of males with paraphilias, paraphilia-related disorders, and sexual coercion may be associated with disinhibited sexual appetite, and an integrated combination of psychotherapeutic and psychopharmacologic interventions are needed to address these conditions. Expand
Current Concepts in the Drug Treatment of Paraphilias and Paraphilia-Related Disorders
SummaryParaphilias are sexual impulse disorders characterised by intensely arousing, recurrent sexual fantasies, urges and activities that are considered ‘deviant’ with respect to cultural norms.Expand


Treatment of sex offenders with antiandrogenic medication: conceptualization, review of treatment modalities, and preliminary findings.
Sexual deviation disorders, or paraphilias, are diagnosable psychiatric syndromes manifested by 1) recurrent fantasies about deviant sex, 2) intense associated cravings, and 3) stereotypic behavioralExpand
47,XYY and 46,XY males with antisocial and/or sex-offending behavior: antiandrogen therapy plus counseling
The combined treatment program was beneficial in helping sex offenders to regulate their behavior and, in five instances, there was a remission of paraphiliac symptoms and the effect on aggressive-destructive antisocial behavior was less clear, and was probably due to a placebo-like response. Expand
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Clinical observations suggest that the drugs are reasonably effective in suppressing libido and sexual arousal in men, but differ somewhat in their pharamcology. Expand
Antilibidinal Drugs and Mental Retardation: A Review
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Of the antilibidinals currently used, medroxyprogesterone acetate and cyproter one acetate are those for which there is most evidence of efficacy. Expand
Postadolescent paraphilic sex offenders: Antiandrogenic and counseling therapy follow-up
Medroxyprogesterone acetate (MP A) is a synthetic progestinic steroid the long -acting form of which is marketed as Depo -Provera® (Upjohn). One of its uses is as an androgen -depleting hormone inExpand
Treatment of sex offenders with Depo-Provera.
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An attempt to evaluate its effectiveness with court committed sexual offenders was made with eight subjects each serving as his own control by alternating Depo-Provera injections for 16 weeks with saline injections for a corresponding 16 weeks. Expand
Medroxyprogesterone acetate (MPA) has a marked antiandrogen property; it is effective in lowering the testosterone level and controlling certain otherwise intractable sex deviations. Expand
Medroxyprogesterone acetate antiandrogen treatment of hypersexuality in a pedophiliac sex offender.
Medroxyprogesterone therapy resulted in decreased libido, few side effects, and no recurrence of sex offenses, but there was no change in the patient's sexual orientation. Expand
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The group of rapists judged to have been the most violent at the time of the offense had a significantly higher mean plasma testosterone level than normals, child molesters, or other rapists in the study, and this relationship was investigated further. Expand