Depo-Provera does not alter disease progression in SIVmac-infected female Chinese rhesus macaques.

@article{SandersBeer2010DepoProveraDN,
  title={Depo-Provera does not alter disease progression in SIVmac-infected female Chinese rhesus macaques.},
  author={Brigitte E Sanders-Beer and Tahar Babas and Keith Mansfield and Dawn Golightly and Joshua David Kramer and Abigail Bowlsbey and Debora Sites and Lourdes Nieves-Duran and Shuling Lin and Sherry Rippeon and Ginger Donnelly and Lowrey L. Rhodes and Yvette Edghill Spano},
  journal={AIDS research and human retroviruses},
  year={2010},
  volume={26 4},
  pages={433-43}
}
Depo-Provera (medroxyprogesterone acetate), a long-acting derivative of progesterone, is utilized during many nonhuman primate microbicide studies to facilitate simian immunodeficiency virus (SIV) infection by thinning the vaginal epithelium. To date, the systemic effects of this steroid hormone in regard to SIV/HIV pathogenesis are not well understood, but an increase in infection rates and lymphoproliferation following progesterone application has been reported. Therefore, a proactive study… CONTINUE READING

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