Depletion of vesicles and fatigue of transmission at a vertebrate central synapse

@article{Model1975DepletionOV,
  title={Depletion of vesicles and fatigue of transmission at a vertebrate central synapse},
  author={Pat G. Model and Stephen M. Highstein and Michael V. L. Bennett},
  journal={Brain Research},
  year={1975},
  volume={98},
  pages={209-228}
}
Synapses from Mauthner to giant fibers in the hatchetfish are chemically transmitting excitatory axo-axonic synapses located in the medulla. The synapses are 4--10 mum in diameter and easily identified for electron microscopy. Presynaptic vesicles are clustered near the contact regions and are round, clear and 40-60 nm in diameter. Stimulation of the Mauthner fiber at 10/sec for 10 min greatly reduces PSP amplitude and causes profound changes in presynaptic structures. Synaptic vesicles become… CONTINUE READING

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