Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability

@article{YunesMedina2018DepletionOT,
  title={Depletion of transglutaminase 2 in neurons alters expression of extracellular matrix and signal transduction genes and compromises cell viability},
  author={Laura Yunes-Medina and Alex R. Paciorkowski and Yan Nuzbrokh and Gail V W Johnson},
  journal={Molecular and Cellular Neuroscience},
  year={2018},
  volume={86},
  pages={72-80}
}
The protein transglutaminase 2 (TG2) has been implicated as a modulator of neuronal viability. TG2's role in mediating cell survival processes has been suggested to involve its ability to alter transcriptional events. The goal of this study was to examine the role of TG2 in neuronal survival and to begin to delineate the pathways it regulates. We show that depletion of TG2 significantly compromises the viability of neurons in the absence of any stressors. RNA sequencing revealed that depletion… CONTINUE READING
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