Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.

  title={Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.},
  author={Peg Miller and Caroline Diorio and Michael Moyer and Rodney C. Schnur and Arnold Bruskin and Walter Cullen and James D. Moyer},
  journal={Cancer research},
  volume={54 10},
Herbimycin A, a benzoquinoid ansamycin, is widely used as an inhibitor of tyrosine kinases. We have examined the effects of herbimycin A and several analogues on p185, the tyrosine kinase encoded by the erbB2 gene in human breast cancer cells. Exposure to 0.35 microM herbimycin A reduced tyrosine phosphorylation of p185 in SKBr3 cells by 80% after 2 h, and the p185 protein level was reduced by 90% after 6 h. The reduction of p185 resulted primarily from increased degradation of p185; cellular… CONTINUE READING


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