Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans

@article{Contreras2008DepletionOT,
  title={Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans},
  author={Vince Contreras and Mark A. Richardson and Enhui Hao and Brett D. Keiper},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1232-1242}
}
During mammalian programmed cell death, cleavage of the translation initiation factor 4G proteins (eIF4GI and eIF4GII) by caspase-3 induces the cap-independent synthesis of pro-apoptotic proteins. Apoptosis occurs naturally in the gonad to remove germ cells that are not selected to grow as oocytes and mature into eggs. Here, we describe two major isoforms of Caenorhabditis elegans eIF4G that are derived from a single gene (ifg-1) and their separate roles in germline homeostasis. Full length IFG… CONTINUE READING

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The genetics of Caenorhabditis elegans

  • S. Brenner
  • Genetics
  • 1974
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