Depletion of striatal dopamine transporter does not affect psychostimulant-induced locomotor activity.

@article{Itzhak1997DepletionOS,
  title={Depletion of striatal dopamine transporter does not affect psychostimulant-induced locomotor activity.},
  author={Yossef Itzhak and Julio L. Martin and S. Fatehyab Ali and M D Norenberg},
  journal={Neuroreport},
  year={1997},
  volume={8 15},
  pages={3245-9}
}
The effect of neurotoxin-induced depletion of striatal dopamine transporter (DAT) binding sites on animals' responses to psychostimulants was investigated. Multiple 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or methamphetamine (METH) injections but not a single METH injection to Swiss Webster mice resulted in > 60% depletion of striatal DAT. MPTP-induced depletion of DAT did not affect METH- and cocaine-stimulated locomotor activity compared with the response of control mice. Pre… CONTINUE READING