Depletion of replenishment of cellular cyclic adenosine monophosphate in hemorrhagic shock.


Hemorrhagic shock in rats was produced by bleeding them to a mean arterial blood pressure of 40 millimeters of mercury, which was maintained for two hours. After sacrifice, small pieces of liver, kidney, muscle and brain were quickly removed and frozen in liquid nitrogen. A protein-free extract of tissues was prepared, and cyclic adenosine monophosphate was… (More)


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