Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection.

@article{Shao2015DepletionOR,
  title={Depletion of regulatory T-cells leads to moderate B-cell antigenicity in respiratory syncytial virus infection.},
  author={Hsiao-Yun Shao and Juo-Yu Huang and Yi-Wen Lin and Shu-Ling Yu and Ebenezer Chitra and Ching-Kun Chang and Wang-Chou Sung and Pele Chong and Y -H Chow},
  journal={International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases},
  year={2015},
  volume={41},
  pages={56-64}
}
OBJECTIVES The regulation of the immunopathology of respiratory syncytial virus (RSV) by regulatory T-cells (CD4(+)CD25(+)Foxp3(+); Tregs) is not understood. METHODS To deduce the same, Tregs were depleted in BALB/c mice by injecting anti-CD25 antibody followed by RSV infection (anti-CD25-RSV mice). RESULTS In this model, a decrease in anti-fusion (F) antibody and neutralizing activity, and an increase in anti-nucleocapsid (N) antibody in serum, were seen. Decreased antibody-dependent cell… CONTINUE READING
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