Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote.

@article{Boumann2005DepletionOP,
  title={Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote.},
  author={Henry A. Boumann and Jacob Gubbens and Martijn C. Koorengevel and Chan-Seok Oh and Charles E. Martin and Albert J. R. Heck and Jana Patton-Vogt and Susan A Henry and Ben de Kruijff and Anton I.P.M. de Kroon},
  journal={Molecular biology of the cell},
  year={2005},
  volume={17 2},
  pages={
          1006-17
        }
}
To study the consequences of depleting the major membrane phospholipid phosphatidylcholine (PC), exponentially growing cells of a yeast cho2opi3 double deletion mutant were transferred from medium containing choline to choline-free medium. Cell growth did not cease until the PC level had dropped below 2% of total phospholipids after four to five generations. Increasing contents of phosphatidylethanolamine (PE) and phosphatidylinositol made up for the loss of PC. During PC depletion, the… CONTINUE READING

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Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids.

  • Proceedings of the National Academy of Sciences of the United States of America
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