Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques.

@article{Reed2004DepletionOP,
  title={Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques.},
  author={Douglas Reed and Lisa E. Hensley and Thomas W Geisbert and Peter B Jahrling and Thomas W. Geisbert},
  journal={Viral immunology},
  year={2004},
  volume={17 3},
  pages={390-400}
}
During the course of an experimentally induced Ebola virus (EBOVA) infection of cynomolgus macaques, peripheral blood mononuclear cells were isolated and characterized by multi-color flow cytometry. Both CD4+ and CD8+ lymphocyte counts decreased 60-70% during the first 4 days after infection. Among CD8+ lymphocytes, this decline was greatest among the CD8(lo) population, which was composed mostly of CD3- CD16+ NK cells. In contrast, the number of CD20+ B lymphocytes in the blood did not… CONTINUE READING
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