Depletion of myocardial glutathione: its effects on heart function and metabolism during ischaemia and reperfusion.

@article{Chatham1988DepletionOM,
  title={Depletion of myocardial glutathione: its effects on heart function and metabolism during ischaemia and reperfusion.},
  author={John C Chatham and A. -M. L. Seymour and E. E. Harmsen and George K. Radda},
  journal={Cardiovascular research},
  year={1988},
  volume={22 11},
  pages={833-9}
}
To determine the importance of intracellular reactive oxygen metabolites in ischaemia and reperfusion, rat hearts were depleted of glutathione, a major intracellular antioxidant, prior to total global or low flow ischaemia. Chronic pretreatment of rats with up to 7 mmol.kg-1 L-buthionine-S,R-sulphoximine over a period of 96 hours resulted in 85% depletion of total myocardial glutathione. Subsequent recovery of glutathione after treatment with the sulphoximine was slow, reaching only 54% of… CONTINUE READING
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