Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4myc myocytes.

@article{Park2005DepletionOM,
  title={Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4myc myocytes.},
  author={Seung Yoon Park and Guem H Choi and Hyo In Choi and Jiwon Ryu and Chan Young Jung and Wan Lee},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 11},
  pages={9855-64}
}
Mitochondrial dysfunction contributes to a number of human diseases, such as hyperlipidemia, obesity, and diabetes. The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the pathogenesis of diabetes. To elucidate the association of cellular mtDNA content and insulin resistance, we produced L6 GLUT4myc myocytes depleted of mtDNA by long term treatment with ethidium bromide. L6 GLUT4myc cells cultured with 0.2 mug/ml ethidium bromide (termed depleted cells… CONTINUE READING

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