Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.

@article{Liu2008DepletionOI,
  title={Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.},
  author={Jing Liu and Yu-gang Jiang and Cheng-yu Huang and Hong-yun Fang and Heng-Tong Fang and Wei Pang},
  journal={Nutritional neuroscience},
  year={2008},
  volume={11 3},
  pages={96-102}
}
Zinc deficiency has been associated with impaired learning and memory function in animals and human beings. However, the molecular mechanisms remain obscure. In light of evidence that ubiquitin C-terminal hydrolase L1 (Uch-L1) and cAMP-responsive element-binding protein (CREB) are required for synaptic and memory function and the possible regulation of CREB by Uch-L1, this present study was conducted to investigate the effect of zinc depletion on Uch-L1 protein expression and on Uch-L1 and CREB… CONTINUE READING
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