Depletion of intracellular calcium stores activates a calcium current in mast cells

@article{Hoth1992DepletionOI,
  title={Depletion of intracellular calcium stores activates a calcium current in mast cells},
  author={Markus Hoth and Reinhold Penner},
  journal={Nature},
  year={1992},
  volume={355},
  pages={353-356}
}
IN many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane1–3. The sustained entry of Ca2+ is thought to result partly from the depletion of intracellular Ca2+ pools4,5. Most investigations have characterized Ca2+ influx indirectly by measuring Ca2+-activated currents6–9 or using Fura-2 quenching by Mn2, which in some cells enters the cells by the same influx pathway10,11. But only a few studies have investigated this Ca2+ entry… CONTINUE READING