Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice

@article{Shojima2012DepletionOH,
  title={Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice},
  author={Nobuhiro Shojima and Kenichiro Hara and Hideo Fujita and Momoko Horikoshi and Nobuhiko Takahashi and Iseki Takamoto and Mitsuru Ohsugi and Hiroyuki Aburatani and Mitsuhiko Noda and Naoto Kubota and Toshimasa Yamauchi and Kohjiro Ueki and Takashi Kadowaki},
  journal={Diabetologia},
  year={2012},
  volume={55},
  pages={3318-3330}
}
Insufficient insulin secretion and reduced pancreatic beta cell mass are hallmarks of type 2 diabetes. Here, we focused on a family of serine-threonine kinases known as homeodomain-interacting protein kinases (HIPKs). HIPKs are implicated in the modulation of Wnt signalling, which plays a crucial role in transcriptional activity, and in pancreas development and maintenance. The aim of the present study was to characterise the role of HIPKs in glucose metabolism. We used RNA interference to… CONTINUE READING

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