Depletion of high-abundant proteins in body fluids prior to liquid chromatography fourier transform ion cyclotron resonance mass spectrometry.

@article{Ramstrm2005DepletionOH,
  title={Depletion of high-abundant proteins in body fluids prior to liquid chromatography fourier transform ion cyclotron resonance mass spectrometry.},
  author={Margareta Ramstr{\"o}m and Charlotte Hagman and Jennifer K Mitchell and Peter J. Derrick and Per H{\aa}kansson and Jonas Bergquist},
  journal={Journal of proteome research},
  year={2005},
  volume={4 2},
  pages={410-6}
}
Today, proteomics is an exciting approach to discover potential biomarkers of different disorders. One challenge with proteomics experiments is the wide concentration range of proteins in various tissues and body fluids. The most abundant component in human body fluids, human serum albumin (HSA), is present at concentrations corresponding to approximately 50% of the total protein content in, e.g., plasma and cerebrospinal fluid (CSF). If this component could be selectively removed, then the… CONTINUE READING