Depletion of glutathione by buthionine sulfoxine is cytotoxic for human neuroblastoma cell lines via apoptosis.

@article{Anderson1999DepletionOG,
  title={Depletion of glutathione by buthionine sulfoxine is cytotoxic for human neuroblastoma cell lines via apoptosis.},
  author={C. D. P. Anderson and Jesse M. Tsai and William E Meek and Rui Ming Liu and Yujie Tang and Henry Jay Forman and C Patrick Reynolds},
  journal={Experimental cell research},
  year={1999},
  volume={246 1},
  pages={183-92}
}
Buthionine sulfoximine (BSO) selectively inhibits glutathione (GSH) synthesis and has been used to sensitize tumor cells to alkylating agents, but has minimal single-agent cytotoxicity for most cell types. We determined the cytotoxicity of BSO for 18 (12 MYCN amplified; 6 MYCN nonamplified) human neuroblastoma cell lines using DIMSCAN, a digital image… CONTINUE READING