Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiologic role for EPI as a natural anticoagulant.

@article{Sandset1991DepletionOE,
  title={Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiologic role for EPI as a natural anticoagulant.},
  author={Per M Sandset and Bonnie J. Warn-Cramer and L Vijaya Mohna Rao and Sonja L. Maki and Samuel I. Rapaport},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 3},
  pages={708-12}
}
Although in vitro experiments have established that extrinsic pathway inhibitor (EPI) is the only known plasma inhibitor of factor VIIa-tissue factor (TF) catalytic activity of potential physiologic significance, evidence of its function in vivo has been lacking. TF-induced intravascular coagulation may occur in patients despite normal plasma levels of EPI and, in our earlier studies, normal plasma EPI levels did not protect rabbits from intravascular coagulation induced by an infusion of… CONTINUE READING