Depletion of either ryanodine- or IP3-sensitive calcium stores activates capacitative calcium entry in mouse anococcygeus smooth muscle cells

@article{Wayman1997DepletionOE,
  title={Depletion of either ryanodine- or IP3-sensitive calcium stores activates capacitative calcium entry in mouse anococcygeus smooth muscle cells},
  author={Chris P Wayman and A. I. Gibson and Ian McFadzean},
  journal={Pfl{\"u}gers Archiv},
  year={1997},
  volume={435},
  pages={231-239}
}
 The properties of the calcium stores coupled to a depletion-operated cation current (I DOC) proposed to underlie capacitative calcium entry were studied in single smooth muscle cells isolated from the mouse anococcygeus using the whole-cell patch-clamp technique. Both caffeine (10 mM) and carbachol (50 μM) activated an initial, large (≈ 200 pA), transient, calcium-dependent chloride current (I ClCa) followed by a smaller (≈ 10 pA) sustained, non-selective cation current (I DOC). Intracellular… CONTINUE READING