Depletion of cellular cholesterol and lipid rafts increases shedding of CD30.

@article{Tresckow2004DepletionOC,
  title={Depletion of cellular cholesterol and lipid rafts increases shedding of CD30.},
  author={Bastian von Tresckow and K Kallen and Elke Pogge von Strandmann and Peter Borchmann and Hans -Walter Lange and Andreas Engert and Hinrich Peter Hansen},
  journal={Journal of immunology},
  year={2004},
  volume={172 7},
  pages={4324-31}
}
CD30, a lymphoid activation marker, is shed into the cell environment after endoproteolytic cleavage of its ectodomain. Soluble (s)CD30 is able to suppress the Th1-type immune response. Because high serum levels of sCD30 and cholesterol-lowering drugs seem to be beneficial in some Th1-type autoimmune diseases, we focused on a link between CD30 shedding and the amount of cellular cholesterol. Cholesterol depletion of human Hodgkin lymphoma- and non-Hodgkin lymphoma-derived cell lines by methyl… CONTINUE READING