Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.

@article{Ulloa1993DepletionOC,
  title={Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.},
  author={Luis Ulloa and Javier D{\'i}az-Nido and Jes{\'u}s {\'A}vila},
  journal={The EMBO journal},
  year={1993},
  volume={12 4},
  pages={1633-40}
}
Casein kinase II is a multifunctional protein kinase which has been implicated in the regulation of cell growth and differentiation. This enzyme is much more abundant in neurons than in any other cell type. The treatment of neuroblastoma cells with an antisense oligodeoxyribonucleotide which specifically results in the depletion of casein kinase II catalytic subunits blocks neuritogenesis. Accordingly, this enzyme may perform an essential role during neurite growth in developing neurons. Casein… CONTINUE READING

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