Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction.

@article{Degos2013DepletionOB,
  title={Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction.},
  author={V Degos and Susana Vacas and Zhenying Han and Nico Van Rooijen and Pierre Gressens and Hua Su and William L. Young and Mervyn M Maze},
  journal={Anesthesiology},
  year={2013},
  volume={118 3},
  pages={527-36}
}
BACKGROUND According to rodent models of postoperative cognitive decline, activation of the innate immune response following aseptic surgical trauma results in the elaboration of hippocampal proinflammatory cytokines, which are capable of disrupting long-term potentiation, the neurobiologic correlate of memory. The authors hypothesize that hippocampal recruitment of bone marrow-derived macrophages plays a causal role in these processes, resulting in memory dysfunction. METHODS Clodrolip… CONTINUE READING