Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice.

@article{Ward2011DepletionOA,
  title={Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice.},
  author={Nicole Ward and Candace M. Loyd and Julie A. Wolfram and Doina Diaconu and Christine Michaels and Thomas S. McCormick},
  journal={The British journal of dermatology},
  year={2011},
  volume={164 4},
  pages={750-8}
}
BACKGROUND There is ongoing debate regarding the initiation of psoriatic plaque as primarily arising from an anomaly in epidermal keratinocytes (KCs) or from abnormalities in immunocytes that secondarily activate otherwise normal KCs. In mice engineered to overexpress the angiopoietin receptor Tie2 in KCs, skin spontaneously develops the characteristic clinical, histological and immune cell phenotypes of psoriasis which can be reversed with either transgene repression or ciclosporin… CONTINUE READING

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