Depletion of alveolar macrophages prolongs survival in response to acute pneumovirus infection.

@article{Rigaux2012DepletionOA,
  title={Depletion of alveolar macrophages prolongs survival in response to acute pneumovirus infection.},
  author={Peter Rigaux and Kristin E. Killoran and Zhijun Qiu and H F Rosenberg},
  journal={Virology},
  year={2012},
  volume={422 2},
  pages={338-45}
}
Alveolar macrophages are immunoregulatory effector cells that interact directly with respiratory virus pathogens in vivo. We examined the role of alveolar macrophages in acute infection with pneumonia virus of mice (PVM), a rodent pneumovirus that replicates the clinical sequelae of severe human respiratory syncytial virus disease. We show that PVM replicates in primary mouse macrophage culture, releasing infectious virions and proinflammatory cytokines. Alveolar macrophages isolated from PVM… CONTINUE READING