Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes

@article{Hartwig2006DepletionOA,
  title={Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes},
  author={U F Hartwig and Marion Nonn and Shahbaj Khan and R Meyer and Christoph Huber and Wolfgang Herr},
  journal={Bone Marrow Transplantation},
  year={2006},
  volume={37},
  pages={297-305}
}
Selective depletion of alloreactive T cells from stem-cell allografts should abrogate graft-versus-host disease while preserving beneficial T cell specificities to facilitate engraftment and immune reconstitution. We therefore explored a refined immunomagnetic separation strategy to effectively deplete alloreactive donor lymphocytes expressing the activation antigen CD69 upon stimulation, and examined the retainment of antiviral, antileukemic, and immunoregulatory T cells. In addition to the… CONTINUE READING

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