Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.

@article{Wang2014DepletionOS,
  title={Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.},
  author={Changshan Wang and Goro Sashida and Atsunori Saraya and Reiko Ishiga and Shuhei Koide and Motohiko Oshima and K. Isono and Haruhiko Koseki and Atsushi Iwama},
  journal={Blood},
  year={2014},
  volume={123 21},
  pages={3336-43}
}
Numerous studies have recently reported mutations involving multiple components of the messenger RNA (mRNA) splicing machinery in patients with myelodysplastic syndrome (MDS). SF3B1 is mutated in 70% to 85% of refractory anemia with ringed sideroblasts (RARS) patients and is highly associated with the presence of RARS, although the pathological role of SF3B1 mutations in MDS-RARS has not been elucidated yet. Here, we analyzed the function of pre-mRNA splicing factor Sf3b1 in hematopoiesis… CONTINUE READING